DOKKYO MEDICAL UNIVERSITY

     This department was founded in 1973 by Professor Ritsuji Yamada as the Department of Clinical Laboratory Medicine and was succeeded in 1993 by Professor Tamio Ieiri.  The current chair is Professor Akira Hishinuma who was appointed in 2010 and is also chair of the Clinical Laboratory Center of Dokkyo Medical University Hospital.  The department is engaged in Education (Medical School, Nursing School, and post-graduation residency) and Research.  The main research area of this department includes genetic analysis of thyroid diseases and genetic identification of bacteria and drug resistance as well as standardization of thyroid function tests.  Anyone who is interested is welcome to contact us. 

      We reported the world’s first case of thyroglobulin mutation and analyzed about 400 cases thereafter.  We extended our research to other gene mutations of congenital hypothyroidism and multi-nodular goiter.  We also established next generation sequencing for thyroid diseases and other endocrine disorders.

      We perform genetic identification of bacteria and fungus by sequencing 16S ribosomal RNA gene and ITC sequences and others. We also do genetic typing of drug resistance genes including carbapenemases, and MRSA among others.

      We are participating in global standardization of thyroid function tests by IFCC (International Federation of Clinical Chemistry and Laboratory Medicine) and held the initiative in implementation of the IFCC activities in Japan.

School of Medicine:

Japanese Society of Laboratory Medicine (JSLM)
Japan Society of Clinical Chemistry (JSCC)
The Japan Association of Clinical Laboratory Science (JCLS)
International Federation of Clinical Chemistry and Laboratory Medicine (IFCC)
American Association of Clinical Chemistry (AACC)
Japan Thyroid Association (JTA)
The Japan Endocrine Society (JES)
The Japan Diabetes Society (JDS)
The Japanese Society of Internal Medicine (JSIM)
American Thyroid Association (ATA)
Asia and Oceania Thyroid Association (AOTA)
Endocrine Society (END)
The Japan Society of Human Genetics
Japanese Society of Genetic Counseling
The Japanese Society for Gene Diagnosis and Therapy
The Japanese Association of Infectious Diseases
Japanese Society of Chemotherapy
Japanese Society for Infection Prevention and Control
Japanese Society of Clinical Microbiology (JSCM)

Education

1981 MD, Gunma University School of Medicine

1986 PhD, Columbia University Graduate School of Arts and Sciences

1993 Doctor of Medical Sciences, Dokkyo University School of Medicine

Career

1986 Postdoctoral Fellow, Department of Physiology,

Yale University School of Medicine

1987 Research Associate, Department of Neurobiology,

Arizona Research Laboratories, University of Arizona

1987 Assistant Professor, Department of Endocrinology,

Dokkyo University School of Medicine

1994 Lecturer, Department of Clinical Laboratory Medicine,

Dokkyo University School of Medicine

1997 Associate Professor, Department of Clinical Laboratory Medicine,

Dokkyo Medical University

2010 Professor, Department of Infection Control and Clinical Laboratory Medicine,

Dokkyo Medical University

Qualifications

1981 Japanese Medical License

1991 Certified Physician, Japanese Society of Internal Medicine

1993 Certified Physician, Japan Diabetes Society

1999 Certified Physician, Japanese Society of Laboratory Medicine

2000 Certified Physician, Japan Society of Clinical Chemistry

2001 Certified Physician of Clinical Genetics, Japanese Society of Human

Genetics and Japanese Society of Genetic Counselor

2004 Certified Physician, Japan Thyroid Association

2009 Infection Control Doctor, Scientific Society Position

1998 Councilor, Japan Thyroid Association

2001 Councilor, Japan Endocrine Society

2001 Councilor, Japanese Society of Laboratory Medicine

2011 Councilor, Japan Society of Clinical Laboratory Automation

2011 Member, Board of Trustees, Japan Thyroid Association

2012 Corresponding member, Committee on Standardization of Thyroid

Function Tests (C-STFT), International Federation of Clinical Chemistry

and Laboratory Medicine (IFCC)

2016 Chair, Committee of Standardization, Japanese Society of Laboratory

2017 Councilor, Japan Society of Clinical Chemistry

2018 Member, Committee on Standardization of Thyroid Function Tests (C-STFT),

International Federation of Clinical Chemistry and Laboratory Medicine (IFCC)

Education

1992 MD, Yamanashi Medical University

1997 PhD, Yamanashi Medical University Graduate School Career

1997 Postdoctoral Research Fellow, UCLA School of Medicine

2001 Assistant Researcher, UCLA School of Medicine, California

2004 Assistant Professor of Medicine, David Geffen School of Medicine at UCLA

2011 Associate Professor of Medicine, David Geffen School of Medicine at UCLA

2013 Associate Professor,

Department of Infection Control and Clinical Laboratory Medicine,

Dokkyo Medical University

2013 Adjunct Lecturer of Laboratory Medicine,

Fukushima Medical University

Qualifications

1992 Japanese Medical License

2016 Certified Physician, Japanese Society of Laboratory Medicine

2017 Infection Control Doctor

2019 Certified Physician, Japanese Society of Clinical Microbiology

Scientific Society Position

2017 Councilor, Japan Endocrine Society

2020 Councilor, Japan Thyroid Association

2000 Active member, The Endocrine Society

2006 Active member, American Thyroid Association

2016 Member, Committee of Standardization,

Japanese Society of Laboratory Medicine

2016 Member, Japanese Society of Clinical Microbiology

2016 Member, Japanese Society of Human Genetics

2017 Member, Japanese Society for Gene Diagnosis and Therapy

Education

2001 MD, Toyama Medical and Pharmaceutical University

2010 PhD, Graduate School of Medicine, The University of Tokyo

Career

2010 The Institute of Medical Science, The University of Tokyo

2012 Department of Infectious Diseases, The University of Tokyo Hospital

2013 Department of Infection Control and Clinical Laboratory Medicine,

Dokkyo Medical University

Kingan, TG and Hishinuma, A.  (1987)
Transport and metabolism of L-glutamic acid by abdominal ganglia of the hawk moth, Manduca sexta.
Comp. Biochem. Physiol. 87c(1): 9-14.

Hishinuma A, Hockfield S, McKay R, and Hildebrand J. G.  (1988)
Monoclonal antibodies reveal cell- type-specific antigens in the sexually dimorphic olfactory system of Manduca sexta. (1) Generation of monoclonal antibodies and partial characterization of the antigens.
J. Neurosci. 8(1); 296-307.

Hishinuma, A., Hockfield, S., McKay, R., and Hildebrand, J. G.  (1988)
Monoclonal antibodies reveal cell- type-specific antigens in the sexually dimorphic olfactory system of Manduca sexta. (2) Expression of the antigens in postembryonic development.
J. Neurosci. 8(1); 308-315.

 Itabashi, H., Hishinuma, A., Yoshida, K., Takano, Y., Naito, T., Sato, A., and Takemura, Y. (1990)
A case of relapsing polychondritis associated with hemolytic anemia.
Japanese Journal of Medicine  29(1): 91-94.

 Namba, J. and Hishinuma, A.(1991)
Correlation of atrial natriuretic peptide concentration in plasma and atria with blood glucose levels in diabetic animals.
Dokkyo J. Med. Sci.  18: 117-125.

 Hishinuma,  A.,  Yamanaka,  T.,  Kasai,  K.,  So,  S., Bamba, N., Motohashi, S., and Shimoda, S.-I.  (1992)
Proliferation of a human thyroid cancer cell line is stimulated by protein tyrosine kinase activity but inhibited by cAMP-dependent protein kinase activity.
J. Endocrinol. Invest.  15 (Suppl. 3): 48

 Kasai, K., Yamaguchi, F., Hosoya, T., Ichimura, K., Bamba, N., Emoto, T., Hiraiwa, M., Hishinuma, A., Hattori, Y., and Shimoda, S.-I.  (1992)
Effects of inorganic iodide, epidermal growth factor and phorbol ester on hormone synthesis by porcine thyroid follicles cultured in suspension.
Life Sci.  51(14): 1095-1103.

Hishinuma,  A.,  Kasai,  K., Ichimura, K., Emoto, T., and Shimoda, S.-I. (1992)
Effects of epidermal growth factor, phorbol ester, and retinoic acid on hormone synthesis and morphology in porcine thyroid follicles cultured in collagen gel.
Thyroid  2(4): 351-359.

 Hishinuma, A., Yamanaka, T., Kasai, K., So, S., Bamba, N., and Shimoda, S.-I. (1994)
Growth regulation of the human papillary thyroid cancer cell line by protein tyrosine kinase and cAMP-dependent protein kinase.
Endocrine J. 41(4): 399-407.

Hishinuma, A., Yamanaka, T., Kasai, K., So, S., Tseng, C-C., Bamba, N., Ohtake, H., and Shimoda S.-I. (1995)
Different growth control of the two human thyroid cell lines of adenomatous goiter and papillary carcinoma.
Thyroid 5(1): 41-46.

Takahashi, K., Suzuki, N., Horiuchi, Y., Hishinuma, A., and Ieiri, T. (1995)
Reproducibility of routine methods using total cholesterol analysis as a model.
Proceedings of the 8th international symposium quality control. pp.120-126.

Hishinuma, A., Yoshida, A., Arimura, M., Kobayashi, T., and Ieiri, T. (1996)
New RT-PCR primers for human thyroglobulin gene.
Dokkyo J. Med. Sci.  23: 79-83.

Arimura, M., Ohuchi, T., Suzuki, Y., Hishinuma, A., Oikawa, S., Sato, J., and Ieiri, T. (1996)
Clinical significance of direct detect of Mycobacterium Tuberculosis in respiratory specimens by polymerase chain reaction.
Dokkyo J. Med. Sci.  23(3): 143-148.
 
Hishinuma, A., Kanno, Y., Kasai, K., Shimoda, S.-I., and Ieiri, T. (1997)
Pathogenesis of a missense mutation in the thyroglobulin gene in a patient with congenital goiter.
Thyroid 7(3):510
 
Hishinuma, A., Takamatsu, J., Kanno, Y., Yoshida, S., and Ieiri, T. (1998)
Analysis of the promoter of the thyrotropin receptor gene and the entire genomic sequence of thyroid transcription factor-1 in familial congenital hypothyroidism due to thyrotropin unresponsiveness.
Thyroid 8(4):305-309.

Hishinuma, A., Kasai, K., Masawa, N., Kanno, Y., Arimura, M., Shimoda, S.-I., and Ieiri, T. (1998)
Missense mutation (C1263R) in the thyroglobulin gene causes congenital goiter with mild hypothyroidism by impaired intracellular transport.
Endocrine J. 45(3):315-327.

 Hishinuma, A., Kuribayashi, T., Kanno, Y., Onigata, K., Nagashima, K., and Ieiri, T. (1998)
Sequence analysis of thyroid transcription factor-1 gene reveals absence of mutations in patients with thyroid dysgenesis but presence of polymorphisms in the 5' flanking region and intron.
Endocrine J. 45(4):563-567.

Hishinuma, A., Ohyama, N., Kanno, Y., Matsuura, N., and Ieiri, T. (1999)
Analysis of thyroglobulin gene in two families with congenital goiter.
Thyroid 9(2):213

 Hishinuma, A., Takamatsu, J., Ohyama, Y., Yokozawa, T., Kanno, Y., Kuma, K., Yoshida, S., Matsuura, N., and Ieiri, T. (1999)
Two novel cysteine substitutions (C1263R and C1995S) of thyroglobulin cause a defect in intracellular transport of thyroglobulin in patients with congenital goiter and the variant type of adenomatous goiter.
J. Clin. Endocrinol. Metab. 84(4):1438-1444.

 Hishinuma, A., Ieiri, T., and Nagakubo, N. (1999)
Increased expression of molecular chaperones and Ire1p kinase in thyroids of goitrous patients with missense mutations of thyroglobulin gene.
XX World Congress of Pathology and Laboratory Medicine pp135-139
Monduzzi Editore S.p.A., Bologna, Italy

Horiuchi, Y., Takanohashi, K., Oikawa, S., Numabe, A., Hishinuma, A., and Ieiri, T. (2000)
Measurement of serum low density lipoprotein-cholesterol in patients with hypertriglycemia.
Electrophoresis  21(2):293-296.

 Kuribayashi, T., Hishinuma, A., Kanazawa, S., Nihei, Y., Hoshi, M., Oyama, M., Nitta, A., Ieiri, T., and Arisaka, O. (2000)
Sequence analysis of thyroid transcription factor-2 (TTF-2) gene in ten patients with congenital hypothyroidism due to thyroid dysgenesis.
Clin. Pediatr. Endocrinol. 9(1):37-40.

Hishinuma, A., Furudate, S., Oh-Ishi, M., Nagakubo, N., Namatame, T., and Ieiri, T. (2000)
A novel missense mutation (G2320R) of the thyroglobulin gene causes hereditary hypothyroidism of the rdw rat.
Endocrinology 141(11):4050-4055.

 Kasai, K., Banba, N., Hishinuma, A., Matsumura, M., Kakishita, H., Matsumura, M., Motohashi, S., Sato, N., and Hattori, Y. (2000)
15-deoxy-Δ12,14-prostaglandin J2 facilitates thyroglobulin production by cultured human thyrocytes.
Am. J. Physiol. Cell Physiol. 279:C1859-1869.

Hishinuma, A., Ohyama, Y., Kuribayashi, T., Nagakubo, N., Namatame, T., Shibayama, K., Arisaka, O., Matsuura, N., and Ieiri, T. (2001)
Polymorphism of the polyalanine tract of thyroid transcription factor-2 gene in patients with thyroid dysgenesis.
Eur. J. Endocrinol. 145(4):385-389.

Ieiri, T., Takahashi, K., Ikeda, M., Takanohashi, K., Matsuda, R., and Hishinuma, A. (2002)
Free T3 assay imprecision during routine testing exceeded an initial estimation using NCCLS EP5-A procedures.
Global Standardization and Advanced Quality Management '01 Quality Control in the Clinical Laboratory, pp84-87, EIBUN PRESS
 
Kita, J., Kobayashi, E., Hishinuma, A., and Kaneda, Y. (2003)
Genetic modification of cold-preserved renal grafts using HSP70 or bcl-2 HVJ-liposome method.
Transplant Immunology 11: 7-14.

Kotani, T., Umeki, K., Kawano, J. I., Suganuma, T., Hishinuma, A., Ieiri, T., and Harada, S. (2003)
Partial iodide organification defect caused by a novel mutation of the thyroid peroxidase gene in three siblings.
Clin. Enodocrinol. 59(2): 198-206.

Baryshev, M., Sargsyan, E., Wallin, G., Lejnieks, A., Furudate, S-I., Hishinuma, A., and Mkrtchian, S. (2004)
Unfolded protein response is involved in the pathology of human congenital hypothyroid goiter and rat non-goitrous congenital hypothyroidism.
J. Mol Endocrinol 32(3):903-20.

Hishinuma, A., Ohmika, N., Namatame, T., and Ieiri, T. (2004)
TTF-2 stimulates expression of 17 genes, including one novel thyroid-specific gene which might be involved in thyroid development.
Mol Cell Endocrinol 221(1-2):33-46.

Nishiyama, S., Mikeda, T., Okada, T., Nakamura, K., Kotani, T., and Hishinuma, A.  (2004)
Transient hypothyroidism or persistent hyperthyrotropinemia in neonates born to mothers with excessive iodine intake.
Thyroid 14(12):1077-83.
 
Shibayama, K., Ohyama, Y., Hishinuma, A., Yokota, Y., Kazahari, K., Kazahari, M., Ieiri, T., Matsuura, N.  (2005)
Subclinical hypothyroidism caused by a mutation of the thyrotropin receptor gene.
Pediatr Int. 47(1):105-8.

Hishinuma, A., Fukata, S., Kakudo, K., Murata, Y., Ieiri, T. (2005)
High Incidence of Thyroid Cancer in Long-standing Goiters with Thyroglobulin Mutations.
Thyroid 15(9):1079-1084
 
Kitanaka, S., Takeda, A., Sato, U., Miki, Y., Hishinuma, A., Ieiri, T., Igarashi, T. (2006)
A novel compound heterozygous mutation in the thyroglobulin gene resulting in congenital goitrous hypothyroidism with high serum triiodothyronine levels.
J Hum Genet 51(4):379-382.
DOI: 10.1007/s10038-006-0360-2

Hishinuma, A., Fukata, S., Nishiyama, S., Nishi, Y., Oh-Ishi, M., Murata, Y., Ohyama, Y., Matsuura, N., Kasai, K., Harada, S., Kitanaka, S., Takamatsu, J., Kiwaki, K., Ohye, H., Uruno, T., Tomoda, C., Tajima, T., Kuma, K., Miyauchi, A., and Ieiri, T. (2006)
Haplotype analysis reveals founder effects of thyroglobulin gene mutations C1058R and C1977S in Japan.
J Clin Endocrinol Metab 91(8):3100-3104.
DOI:10.1210/jc.2005-2702

Nishihara, E., Fukata, S., Hishinuma, A., Kudo, T., Ohye, H., Ito, M., Kubota, S., Amino, N., Kuma, K., Miyauchi, A. (2006)
Sporadic congenital hyperthyroidism due to a germline mutation in the thyrotropin receptor gene (Leu512Gln) in a Japanese patient.
Endocrine J. 53(6):735-740.
DOI:10.1507/endocrj.K06-090
 
Hishinuma, A., Fukata, S., and Ieiri, T. (2007)
Emerging new features of patients with thyroglobulin mutations, including increased incidence of thyroid cancer.
Hot Thyroidology (European Thyroid Association) August, No2:1-10

Kanou Y, Hishinuma A, Tsunekawa K, Seki K, Mizuno Y, Fujisawa H, Imai T, Miura Y, Nagasaka T, Yamada C, Ieiri T, Murakami M, Murata Y. (2007)
Thyroglobulin gene mutations producing defective intracellular transport of thyroglobulin are associated with increased thyroidal type 2 iodothyronine deiodinase activity.
J Clin Endocrinol Metab 92(4):1451-1457.
DOI: 10.1210/jc.2006-1242

Fukata, S., Hishinuma A., Kuma, K., Miyauchi, A., Sugawara, M  (2007)
Letter to the Editor
Endemic goiter due to thyroglobulin gene abnormality and social ostracism.
Endocrine J. 54(3):485-486.

Nishihara, E., Nagayama, Y., Amino, N., Hishinuma, A., Takano, T., Yoshida, H., Kubota, S., Fukata, S., Kuma, K., Miyauchi, A. (2007)
A Novel Thyrotropin Receptor Germline Mutation (Asp617Tyr) Causing Hereditary Hyperthyroidism.
Endocrine J. 54 (6):927-934.
DOI:10.1507/endocrj.K07-088

Ohye, H., Fukata, S., Hishinuma, A., Kudo, T., Nishihara, E., Ito, M., Kubota, S., Amino, N., Ieiri, T., Kuma, K., Miyauchi, A. (2008)
A Novel Homozygous Missense Mutation of the Dual Oxidase 2 (DUOX2) Gene in an Adult Patient with Large Goiter.
Thyroid 10(5): 561-566.
DOI: 10.1089/thy.2007.0258

Fukata S、Hishinuma A、Nakatake N、 Tajiri J. (2010)
Diagnosis of Iodide Transport Defect: Do We Need to Measure the Saliva/Serum Radioactive Iodide Ratio to Diagnose Iodide Transport Defect?
Thyroid 20(12): 1419-1421.
DOI: 10.1089/thy.2010.0069

Chihara S、Okuzumi K、Yamamoto Y、Oikawa S、Hishinuma A. (2011)
First Case of New Delhi Metallo-β-Lactamase 1 (NDM-1) Producing Escherichia coli Infection in Japan.
Clin Infect Dis 52(1): 153-154.
DOI: 10.1093/cid/ciq054

Yamamoto T, Takano T, Iwao Y, Hishinuma A. (2011)
Emergence of NDM-1-positive capsulated Escherichia coli with high resistance to serum killing in Japan.
J Infect Chemother 17: 435-439.
DOI: 10.1007/s10156-011-0232-3

Sekizuka T, Matsui M, Yamane K, Takeuchi F, Ohnishi M, Hishinuma A, Arakawa Y, Kuroda M. (2011)
Complete sequencing of the blaNDM-1-positive plasmid from Escherichia coli ST38 type isolate reveals a novel composite transposon in IncA/C plasmid and suggests a possible origination of blaNDM-1 from plant pathogenic bacteria.
PLOS ONE.  6(9): e25334
DOI: 10.1371/journal.pone.0025334

Kahara T, Igarashi N, Hishinuma A, Nakanishi Y, Uchiyama A, Miwa A, Ishizawa S, Yamamoto Y, Noto H, Sumiya H,,Ishikura K, Usuda R, Iida H. (2012)
Thyroglobulin gene mutation with cold nodule on thyroid scintigraphy.
Case Reports in Endocrinology
Volume 2012, Article ID 280319
DOI:10.1155/2012/280319
 
Fukata S, Hishinuma A, Nakatake N, Tajiri J. (2012)
A Japanese Family with Familial Nonautoimmune Hyperthyroidism with a Novel Mutation (Asn406Ser) in Extracellular Domain of Thyrotropin Receptor.
Clin Endocrinol 77:329-330
DOI: 10.1111/j.1365-2265.2011.04324.x.

Sakurai K, Hata M, Hishinuma A, Ushijima R, Okada A, Taeda Y, Arihara Z, Fukazawa H, Takahashi K. (2013)
Papillary thyroid carcinoma in one of identical twin patients with Pendred syndrome.
Endocrine J. 60(6):805-811.
DOI: 10.1507/endocrj. EJ12-0396
 
Fujisaki M, Sadamoto S, Hishinuma A. (2013)
Evaluation of the double-disk synergy test for New Delhi metallo-β-lactamase-1 and other metallo-β-lactamase producing gram-negative bacteria by using metal-ethylenediaminetetraacetic acid complexes.
Microbiol Immunol. 57(5):346-352.
DOI: 10.1111/j.1348-0421.12042

Hishinuma A, Yoshida A, Suzuki H, Okuzumi K, Ishida T. (2013)
Complete sequencing of an IncFII NDM-1 plasmid in Klebsiella pneumoniae shows structural features
shared with other multidrug-resistant plasmids.
J Antimicrob Chemother 68(10):2415-2417.
DOI:10.1093/jac/dkt190

Hagiwara S, Yoshida A, Omata Y, Tsukada Y, Takahashi H, Kamewada H, Koike S,
Okuzumi K, Hishinuma A, Kobayashi K, Nakano M. (2013)
Desulfovibrio desulfuricans bacteremia in a patient hospitalized with acute cerebral infarction:
Case report and review.
J Infect Chemother. 20(4):274-277.
DOI: 10.1016/j.jiac.2013.10.009.

Nishihara E, Fukata S, Hishinuma A, Amino N, Miyauchi A. (2014)
Prevalence of Thyrotropin Receptor Germline Mutations and Clinical Courses in 89 Hyperthyroid Patients with Diffuse Goiter and Negative Anti-Thyrotropin Receptor Antibodies.
Thyroid 24(5):789-795.
DOI: 10.1089/thy.2013.0431
 
Satou M, Nishi Y, Hishinuma A, Hosoda H, Kangawa K, Sugimoto H (2015)
Identification of activated protein C as a ghrelin endopeptidase in bovine plasma.
J Enodocrinol. 224(1):61-73.
DOI: 10.1530/JOE-14-0529

Toyoda S, Tajima E, Fukuda R, Masawa T, Inami S, Amano H, Arikawa T, Yoshida A, Hishinuma A, Inoue T (2015)
Early surgical intervention and optimal medical treatment for Candida parapsilosis endocarditis.
Intern Med 54: 411-413, 2015.
 
Taki K, Kogai T, Sakumoto J, Namatame T, Hishinuma A (2015)
Familial hypocalciuric hypercalcemia with a de novo heterozygous mutation of calcium-sensing receptor.
Endocrinology, Diabetes and Metabolism 15-0016, 2015.
DOI: 10.1530/EDM-15-0016
 
Suzuki H, Yoshida S, Yoshida A, Okuzumi K, Fukusima A, Hishinuma A  (2015)
A novel cluster of Mycobacterium abscessus complex revealed by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS)
Diagn Microbiol Infect Dis 83:365-370, 2015
DOI: 10.1016/j.diagmicrobio.2015.08.011.

Mizokami T, Hishinuma A, Kogai T, Hamada K, MarutaT, HigashiK, Tajiri J (2016)
Graves’ disease and Gitelman syndrome
Clin Endo 84:149-150.
DOI: 10.1111/cen.12829
 
Mizokami T, Fukata S, Hishinuma A, Kogai T, Hamada K, Maruta T, Higashi K, Tajiri J  (2016)
Iodide transport defect and breast milk iodine
Eur Thyroid J 5:145–148
DOI: 10.1159/000446496

Kimura M, Araoka H, Yoshida A, Yamamoto H, Abe M, Okamoto Y, Yuasa M, Kaji D, Kageyama K, Nishida A, Ishiwata K, Takagi S, Yamamoto G, Asano-Mori Y, Uchida N, Hishinuma A, Izutsu K, Wake A, Taniguchi S, Yoneyama A (2016)
Breakthrough viridans streptococcal bacteremia in allogeneic hematopoietic stem cell transplant recipients receiving levofloxacin prophylaxis in a Japanese hospital
BMC Infectious Diseases 16:372
DOI: 10.1186/s12879-016-1692-y
 
Nishihara E, Hishinuma A, Kogai T, TakadaN, Hirokawa M, Fukata S, Ito M, Yabuta T, Nishikawa M, Nakamura H, Amino N, Miyauchi A (2016)
A Novel Germline Mutation of KEAP1 (R483H) Associated with a Non-Toxic Multinodular Goiter
Front Endocrinol 7:Article 131
DOI: 10.3389/fendo.2016.00131
 
Thienpont LM, Van Uytfanghe K, De Grande LC, Reynders D, Das B, Faix JD, MacKenzie F, Patru M-M, Rottmann M, Decallonne B, Hishinuma A, Lapauw B, Taelman P, Van Crombrugge P, Van den Bruel A, Velkeniers B, Williams P, on behalf for the IFCC Committee for Standardization of Thyroid Function Tests (C-STFT) (2017)
Harmonization of serum thyroid-stimulating hormone measurements paves the way for the adoption of a more uniform reference interval
Clin Chem 63(7): 1248-1260.
DOI:10.1373/clinchem.2016.269456
 
De Grande LC, Van Uytfanghe K, Reynders D, Das B, Faix JD, MacKenzie F, Decallonne B, Hishinuma A, Lapauw B, Taelman P, Van Crombrugge P, Van den Bruel A, Velkeniers B, Williams P, Thienpont LM, on behalf for the IFCC Committee for Standardization of Thyroid Function Tests (C-STFT) (2017)
Standardization of free thyroxine measurements allows the adoption of a more uniform reference interval
Clin Chem 63(10):1642-1652.
DOI:10.1373/clinchem.2017.274407
 
Nyuzuki H, Kogai T, Hishinuma A, Ogawa Y, Saitoh A, Nagasaki K (2017)
PTEN mutation in a Japanese boy with autonomously functioning thyroid nodule.
Pediatrics International 59: 1223–1224.
DOI: 10.1111/ped.13427

Yoshihara A, Yoshimura NJ, Watanabe N, Iwaku K, Kunii Y, Ohye H, Suzuki M, Matsumoto M, Suzuki N, Sugino K, Thienpont LM, Hishinuma A, Ito K (2018)
Seasonal Changes in Serum Thyrotropin Concentrations Observed from Big Data Obtained During Six Consecutive Years from 2010 to 2015 at a Single Hospital in Japan
Thyroid 28(4): 429-436.
DOI.org/10.1089/thy.2017.0600
 
Mizokami T, Fukata S, Kogai T, Hishinuma A, Hamada K, Maruta T, Higashi K, Tajiri J (2019)
Congenital Primary Hypothyroidism with the Homozygous Nonsense Mutation P.K1374* in the Thyroglobulin Gene and a Normal-sized Thyroid Gland on Levothyroxine Replacement.
Internal Medicine
DOI: 10.2169/internalmedicine.1163-18
 

Nagamine T, Yoshimura JN, Emoto N, Kogai K, Hishinuma A, Okajima F, Sugihara H（2019）
Painless destructive thyroiditis in a patient with resistance to thyroid hormone: a case report..
Thyroid Res 12:8
 
Okazaki Y, Arata N, Umehara N, Yamauchi T, Tajiri J, Hishinuma A, Kogai T, Idegami T, Murashima A, Sago H (2020)
A Case of Familial Nonautoimmune Hyperthyroidism During Pregnancy
AACE Clinical Case Reports 6 (2) e94-e97.
DOI: https://journals.aace.com/doi/...

Kishi H, Jojima T, Kogai T, Iijima T, Ohira E, Tanuma D, Konno S, Kato K, Kezuka A, Akimoto K, Sakumoto J, Hishinuma A, Tomaru T, Makita N, Usui U, Aso Y (2020)
A case of hypoparathyroidism, deafness, and renal dysplasia (HDR) syndrome with a novel frameshift variant in GATA3, p.W10Cfs40, lacks kidney malformation.
Clinical Case Reports 00: 1-6.
DOI: 10.1002/ccr3.3186

Department of Infection Control and Clinical Laboratory Medicine
Dokkyo Medical University
Kitakobayashi 880, Mibu, Shimotsuga, Tochigi, 321-0293 Japan
TEL: 81-282-87-2139
FAX: 81-282-86-6212
a-hishi@dokkyomed.ac.jp
 
See more details : https://dept.dokkyomed.ac.jp/dep-m/icclm/ (in Japanese)