Department of Pediatrics

Head of the Department: Shigemi Yoshihara, MD, PhD

Message from the Head of the Department

     We provide medical care through our pediatrics staff in good faith to protect the future of children. Since pediatrics covers a very wide range of medical care including pediatric emergency and perinatal care, we can diagnose all kinds of children's diseases. This refers to general physicians who practice it. At the same time, it is important to train specialists with specialized subspecialties in order to provide advanced medical care. There are experts who can teach the process, and all the members of the class cooperate to provide comprehensive medical care for children.
     Research and medical care are one, and we believe that research is the foundation for conducting advanced medical care in university hospitals. Therefore, we are implementing the research activities in the classes and always aiming for internationally acclaimed research activities. In addition, we are teaching research that can be as close as possible to the development of pediatric medicines.


1. Clinical Activities
Allergic diseases: bronchial asthma, food allergy, anaphylaxis, atopic dermatitis, allergic rhinitis including pollinosis, oral allergy syndrome, allergic conjunctivitis, bee venom allergy, etc.
Respiratory diseases: chronic lung disease (including the need for home oxygen), chronic cough, etc.
Infectious diseases: acute bronchiolitis, mycoplasma pneumoniae, croup syndrome, meningitis, urinary tract infection, etc.
Blood and Tumor diseases: leukemia, malignant lymphoma, neuroblastoma, hepatoblastoma, Wilms tumor, immune thrombocytopenic purpura, aplastic anemia, hemophilia, etc.
Immunodeficiency/Autoinflammatory diseases: immunodeficiency, PFAPA syndrome, familial Mediterranean fever, etc.
Neurological disorders: epilepsy, incurable neurological diseases, muscular disorders, etc.
Endocrine disorders: short stature, disorders of puberty development, thyroid disease, adrenal disease, genital abnormalities, diabetes, obesity, lifestyle diseases, metabolic syndrome, etc.
Metabolic disorders: detection cases of newborn tandem mass spectrometry, etc.
Kidney diseases: nephrosis, chronic renal disease, abnormal findings in school urinalysis, nocturia, enuresis, neurogenic bladder, peritoneal dialysis, etc.
Collagen disease: Kawasaki disease, juvenile idiopathic arthritis, systemic lupus erythematosus, juvenile dermatomyositis, etc.
Heart diseases: Kawasaki disease with cardiac complications, congenital heart disease, pulmonary hypertension, arrhythmia, fetal cardiac ultrasonography, etc.

2.Research Activities

  • Yoshihara S, Morimoto H, Yamada Y, Abe T, Arisaka O: Cannabinoid receptor agonists inhibit sensory nerves activation in guinea pig airways. Am J Respir Crit Care Med 170: 941-946, 2004.
  • Yoshihara S, Yamada Y, Abe T, Lindén A, Arisaka O: Association of epithelial damage and signs of neutrophil mobilization in the airways during acute exacerbations of pediatric asthma. Clin Exp Immunol 144 212-216, 2006.
  • Yamada Y, Yoshihara S: Creola bodies in infancy with respiratory syncytial virus bronchiolitis predict the development of asthma. Allergol Int 59: 375-380, 2010.
  • Yoshihara S, Kusuda S, Mochizuki H, Okada K, Nishima S, Simões EA: Effect of palivizumab prophylaxis on subsequent recurrent wheezing in preterm infants. Pediatrics 132: 811-818, 2013.
  • Yoshihara S, Munkhbayarlakh S, Makino S, Ito C, Narantsetseg L, Sarangerel D, Sagara H, Fukuda T, Arisaka O: Prevalence of childhood asthma in Ulaanbaatar, Mongolia in 2009. Allergol Int 65: 62-67, 2016.
  • Sugai K, Kimura H, Miyaji Y, Yoshizumi M, Tsukagoshi H, Sasaki-Sakamoto T, Noda M, Yamada Y, Ikeda M, Kozawa K, Ryo A, Yoshihara S, Ogata H, Okayama Y: MIP-1α level in nasopharyngeal aspirates at the first wheezing episode predicts recurrent wheezing. J Allergy Clin Immunol, 137:774-781 2016.
  • Mochizuki H, Kusuda S, Okada K, Yoshihara S, Furuya H, Simões EAF: Palivizumab Prophylaxis in Preterm Infants and Subsequent Recurrent Wheezing. Six-Year Follow-up Study. Am J Respir Crit Care Med. 196:29-38, 2017.
  • Yoshihara S, Tsubaki T, Ikeda M, Lenney W, Tomiak R, Hattori T, Hashimoto K, Soutome T, Kato S: The efficacy and safety of fluticasone/salmeterol compared to fluticasone in children younger than four years of age. Pediatr Allergy Immunol. 30(2):195-203, 2019.

3. Education
School of Medicine:

1st year Lectures on Doctor’s Career Plan
2nd year Patient Bedside Learning (PBL) Tutorial Ⅱ
3rd year Lectures on Pediatrics
4th year Lectures on Pediatrics
5th year Clinical Clerkship in Pediatrics
6th year Advanced Clinical Clerkship (ACC)
Growth and Developmental disorders

Research Fields

  • Molecular biological research on the pathophysiology and treatment of airway inflammation
  • Research on allergen components of food allergies
  • Research on bronchial end breath onset and exacerbation of airway virus infection
  • Prevention of respiratory disorders and chronic lung diseases in preterm infants and treatment studies
  • Molecular biological studies on the pathophysiology and treatment of growth disorders
  • Epidemiological and biochemical studies on pediatric metabolic syndrome
  • Studies on the pathophysiology and treatment of malignant neoplasms and blood disorders in children
  • Genetic study of pediatric swelling disease
  • Study on pathophysiology and treatment of pediatric epilepsy
  • Clinical study of pediatric heart disease
  • Study on etiology and treatment of Kawasaki disease

Academic Society Activities

Japan Pediatric Society
Japanese Society of Allergology
Japanese Society of Pediatric Allergy and Clinical Immunology
Japanese Society of Pediatric Pulmonology
The Japanese Society of Pediatric Hematology/Oncology 
The Japan Endocrine Society
Japan Society for the Study of Obesity
The Japanese Society of Child Neurology
Japan Epilepsy Society
The Japanese Association for Infectious Diseases
Japanese Society for Pediatric Infectious Diseases
Japan Society of Perinatal and Neonatal Medicine
The Japanese Circulation Society


Professor and Chairman Shigemi Yoshihara, MD, PhD
Special Appointed Professor Kenichi Sugita, MD, PhD
Special Appointed Professor Junichi Hirao, MD, PhD
Associate Professor Hiroshi Suzumura, MD, PhD
Associate Professor George Imataka, MD, PhD
Associate Professor Yuya Sato, MD, PhD
Associate Professor Satomi Koyama, MD, PhD
Senior Assistant Professor Keitaro Fukushima, MD, PhD
Senior Assistant Professor Yoshiyuki Watabe, MD, PhD
Senior Assistant Professor Kaori Sekine, MD, PhD
Senior Assistant Professor Mayuko Okuya, MD, PhD
Senior Assistant Professor Yusuke Ando, MD, PhD
Senior Assistant Professor Yuji Kano, MD, PhD

and 52 others

Characteristics of the Department

     In pediatrics, we cover allergies, respiratory organs, infections, hematoma, nerves, endocrine metabolism, renal urinary organs, circulatory organs, etc. All the members of the class work together with the experts and instructors who also practice it so that they can provide comprehensive medical care for children.


Department of Pediatrics
Dokkyo Medical University
Kitakobayashi 880, Mibu, Shimotsuga, Tochigi, 321-0293 Japan
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